The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
< 0.100 Eu/µg
>95% by SDS-PAGE .
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C.
Constituent: 100% PBS
Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
C type lectin domain family 6 member A
C type lectin superfamily member 10
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10
C-type lectin domain family 6 member A
C-type lectin superfamily member 10
CLEC4N, mouse, homolog of
DC associated C type lectin 2
DC-associated C-type lectin 2
Dendritic cell associated lectin 2
Dendritic cell-associated C-type lectin 2
Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway.
Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids.
Contains 1 C-type lectin domain.
A short stretch of the intracellular domain (AA 8-14) proximal to the transmembrane domain is required for association with Fc receptor gamma chain.