Recombinant Human Desmoglein 1 protein (ab114443)

Overview

  • Product nameRecombinant Human Desmoglein 1 protein
  • Protein lengthFull length protein

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionQ02413
    • SpeciesHuman
    • SequenceMDWSFFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKRE WIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIF VINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDI NDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIR QEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMS AECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFS ANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIG VRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGS NDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTK EQYNMLGGKYQGTILSIDDNLQRTCTGTININIQSFGNDDRTNTEPNTKI TTNTGRQESTSSTNYDTSTTSTDSSQVYSSEPGNGAKDLLSDNVHFGPAG IGLLIMGFLVLGLVPFLMICCDCGGAPRSAAGFEPVPECSDGAIHSWAVE GPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYGGREMQDLGGGER MTGFELTEGVKTSGMPEICQEYSGTLRRNSMRECREGGLNMNFMESYFCQ KAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSFLDT LGPKFKKLADISLGKESYPDLDPSWPPQSTEPVCLPQETEPVVSGHPPIS PHFGTTTVISESTYPSGPGVLHPKPILDPLGYGNVTVTESYTTSDTLKPS VHVHDNRPASNVVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIA PSSSLPTSLTIHHPRESSNVVVTERVIQPTSGMIGSLSMHPELANAHNVI VTERVVSGAGVTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGG IGLSSLGGTASIGHMRSSSDHHFNQTIGSASPSTARSRITKYSTVQYSK
    • Molecular weight142 kDa including tags
    • Amino acids1 to 1049

Specifications

Our Abpromise guarantee covers the use of ab114443 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • Cadherin family member 4
    • CDHF4
    • Desmoglein-1
    • Desmosomal glycoprotein 1
    • DG1
    • DGI
    • DSG
    • DSG1
    • DSG1_HUMAN
    • EPKHE
    • EPKHIA
    • Pemphigus foliaceus antigen
    • PPKS1
    • SPPK1
    see all
  • FunctionComponent of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
  • Tissue specificityEpidermis, tongue, tonsil and esophagus.
  • Involvement in diseaseDefects in DSG1 are the cause of palmoplantar keratoderma striate type 1 (SPPK1) [MIM:148700]; also known as keratosis palmoplantaris striata I. SPPK1 is a dermatoligical disorder characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger.
  • Sequence similaritiesContains 4 cadherin domains.
  • DomainCalcium may be bound by the cadherin-like repeats.
  • Cellular localizationCell membrane. Cell junction > desmosome.
  • Information by UniProt

Recombinant Human Desmoglein 1 protein images

  • ab114443 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

References for Recombinant Human Desmoglein 1 protein (ab114443)

ab114443 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"