The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
DEXH (Asp Glu X His) box polypeptide 58
DEXH box polypeptide 58
Ortholog of mouse D11lgp2
Probable ATP dependent helicase LGP2
Probable ATP dependent RNA helicase DHX58
Probable ATP-dependent helicase LGP2
Probable ATP-dependent RNA helicase DHX58
Protein D11Lgp2 homolog
RIG-I-like receptor LGP2
RNA helicase LGP2
Participates in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade which results in the induction and expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). The RNA helicase domain may recognize and structurally modify viral RNA to facilitate detection by DDX58/RIG-I or by IFIH1/MDA5 whose affinity for dsRNA is lower.
Belongs to the helicase family. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain.