• NatureRecombinant
  • SourceHEK 293 cells
  • Amino Acid Sequence
    • AccessionO00548
    • SpeciesHuman
    • Molecular weight70 kDa including tags
    • Amino acids1 to 545
    • TagsDDDDK tag C-Terminus


Our Abpromise guarantee covers the use of ab108576 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityInhibits adipogenesis of mesenchymal stem cells.
  • Applications

    Functional Studies


  • Endotoxin level< 0.100 Eu/µg
  • Purity> 90 % SDS-PAGE.
    ab108576 is 0.2µm filtered
  • FormLiquid
  • Additional notesWorking aliquots are stable for up to 3 months when stored at -20°C. Inhibits adipogenesis of mesenchymal stem cells.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: PBS

General Info

  • Alternative names
    • Delta
    • Delta (Drosophila) like 1
    • Delta like 1
    • Delta like 1 (Drosophila)
    • Delta like 1 protein
    • Delta like protein 1
    • Delta like protein 1 precursor
    • Delta, Drosophila, homolog of 1
    • Delta-like protein 1
    • Delta1
    • DL1
    • DLL 1
    • DLL1
    • DLL1_HUMAN
    • Drosophila Delta homolog 1
    • H-Delta-1
    • OTTHUMP00000017690
    see all
  • FunctionActs as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.
  • Tissue specificityExpressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.
  • Sequence similaritiesContains 1 DSL domain.
    Contains 8 EGF-like domains.
  • Post-translational
    Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.
  • Cellular localizationMembrane.
  • Information by UniProt

Recombinant Human DLL1 protein images

  • Adipogenesis inhibition of MSCs.
    MSCs (Mesenchymal stem cells) were maintained in DMEM, supplemented with 10% fetal bovine serum, penicilin-streptomycin and glutamine. For differentiation of MSCs, MSCs were cultured in adipogenic medium which was growth medium supplemented with 1µM Dexamethasone, 0.5mM IBMX, 10µg/m lnsulin, 100µM Indomethacin (day 1). Medium was changed every 3 days. Staining with Oil Red O was typically performed on day 30. For negative controls, TNF-alpha (20ng/ml) was added. To immobilize Notch ligands on the plastic surface of the culture plates, plates were first incubated with a solution of anti-FLAG® antibody (10µg/ml) in PBS for 30 mins at 37°C. Coated plates were blocked with growth medium for at least 30mins, incubated with solution of ab108576 (5µg/ml) or mCD137L-FLAG® (5µg/ml) in growth medium for 2 hours at 37°C. Plates were then used to differentiate MSCs.

References for Recombinant Human DLL1 protein (ab108576)

ab108576 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab108576.
Please use the links above to contact us or submit feedback about this product.