Recombinant Human DNAJB6 protein (ab105132)

Overview

  • Product nameRecombinant Human DNAJB6 protein
  • Protein lengthFull length protein

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionO75190
    • SpeciesHuman
    • Sequenceab105132 is purified using conventional chromatography techniques.
    • Molecular weight39 kDa including tags
    • Amino acids1 to 326
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab105132 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity> 85 % SDS-PAGE.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 30% Glycerol, 0.2M Sodium chloride, 5mM DTT, 20mM Tris HCl, pH 8.0

General Info

  • Alternative names
    • DJ4
    • DnaJ
    • DnaJ (Hsp40) homolog subfamily B member 6
    • DNAJ B6
    • DnaJ homolog subfamily B member 6
    • DnaJ like 2 protein
    • DNAJB6
    • DNJB6_HUMAN
    • Heat shock protein J2
    • HHDJ1
    • HSJ-2
    • HSJ2
    • LGMD1E
    • MRJ
    • MSJ-1
    • MSJ1
    see all
  • FunctionPlays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.
  • Tissue specificityWidely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher level in hippocampus and thalamus and a lower level in amygdala, substantia nigra, corpus callosum and caudate nucleus.
  • Involvement in diseaseLimb-girdle muscular dystrophy 1E
  • Sequence similaritiesContains 1 J domain.
  • DomainThe antiaggregation activity of isoform B resides in the serine-rich region and the C-terminus.
  • Cellular localizationCytoplasm, perinuclear region. Nucleus. Cytoplasm, myofibril, sarcomere, Z line.
  • Information by UniProt

Recombinant Human DNAJB6 protein images

  • 15% SDS-PAGE showing ab105132 (3 µg) at approximately 38.5 kDa.

References for Recombinant Human DNAJB6 protein (ab105132)

ab105132 has not yet been referenced specifically in any publications.

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