Recombinant Human DNAJC15 protein (ab162220)

Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MAARGVIAPVGESLRYAEYLQPSAKRPDADVDQQGLVRSLIAVGLGVAAL AFAGRYAFRIWKPLEQVITETAKKISTPSFSSYYKGGFEQKMSRREAGLI LGVSPSAGKAKIRTAHRRVMILNHPDKGGSPYVAAKINEAKDLLETTTKH
    • Amino acids
      1 to 150
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab162220 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • Cell growth inhibiting gene 22 protein
    • Cell growth-inhibiting gene 22 protein
    • DJC15_HUMAN
    • DnaJ (Hsp40) homolog subfamily C member 15
    • DNAJ domain containing
    • DnaJ homolog subfamily C member 15
    • DNAJC15
    • DNAJD1
    • GIG22
    • HSD18
    • MCJ
    • Methylation controlled J protein
    • Methylation-controlled J protein
    see all
  • Function
    Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.
  • Tissue specificity
    Expressed at highest levels in heart, followed by liver and kidney.
  • Involvement in disease
    Absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin.
  • Sequence similarities
    Contains 1 J domain.
  • Cellular localization
    Mitochondrion inner membrane.
  • Information by UniProt

Images

  • ab162220 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab162220 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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