Recombinant Human DNAJC19 protein (ab104153)

Overview

  • Product nameRecombinant Human DNAJC19 protein
  • Protein lengthProtein fragment

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ96DA6
    • SpeciesHuman
    • SequenceMRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMGRY VLQAMKHMEP QVKQVFQSLP KSAFSGGYYR GGFEPKMTKR EAALILGVSP TANKGKIRDA HRRIMLLNHP DKGGSPYIAA KINEAKDLLE GQAKK
    • Molecular weight15 kDa including tags
    • Amino acids19 to 116
    • TagsHis tag N-Terminus , DDDDK tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab104153 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry
    MALDI-TOF
  • Purity> 90 % SDS-PAGE.
    purified by using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20mM Tris pH 7.5, 2mM EDTA.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 2mM DTT, pH 8.0

General Info

  • Alternative names
    • DnaJ (Hsp40) homolog, subfamily C, member 19
    • DnaJ homolog subfamily C member 19
    • DNAJC19
    • homolog of yeast TIM14
    • Mitochondrial import inner membrane translocase subunit TIM14
    • PAM18
    • TIM 14
    • TIM14
    • TIM14_HUMAN
    • TIMM 14
    • TIMM14
    • translocase of the inner mitochondrial membrane 14
    • Translocase of the inner mitochondrial membrane 14, yeast homolog of
    see all
  • FunctionProbable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity.
  • Tissue specificityUbiquitously expressed.
  • Involvement in diseaseDefects in DNAJC19 are the cause of 3-methylglutaconic aciduria type 5 (MGA5) [MIM:610198]; also known as dilated cardiomyopathy with ataxia (DCMA). MGA5 is an autosomal recessive disorder characterized by early-onset dilated cardiomyopathy, growth failure, cerebellar ataxia causing significant motor delays, testicular dysgenesis, growth failure, and significant increases in urine organic acids, particularly 3-methylglutaconic acid and 3-methylglutaric acid.
  • Sequence similaritiesBelongs to the TIM14 family.
    Contains 1 J domain.
  • Cellular localizationMitochondrion inner membrane.
  • Information by UniProt

Recombinant Human DNAJC19 protein images

  • 15% SDS-PAGE, 3ug of ab104153 loaded

References for Recombinant Human DNAJC19 protein (ab104153)

ab104153 has not yet been referenced specifically in any publications.

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