Overview

Description

  • Nature
    Recombinant
  • Source
    HEK 293 cells
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      100 kDa including tags
    • Amino acids
      1 to 640
    • Tags
      DDDDK tag C-Terminus

Specifications

Our Abpromise guarantee covers the use of ab108954 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Endotoxin level
    < 0.100 Eu/µg
  • Purity
    > 90 % SDS-PAGE.
    ab108954 is 0.2µm filtered.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: PBS

General Info

  • Alternative names
    • bet
    • Brain EGF repeat-containing transmembrane protein
    • Bret
    • Delta and Notch-like epidermal growth factor-related receptor
    • Delta notch like EGF repeat containing transmembrane
    • Delta/notch like EGF repeat containing
    • Delta/notch-like EGF-related receptor
    • Dner
    • DNER_HUMAN
    • PRO299
    • Transmembrane protein Bet
    • UNQ26
    see all
  • Function
    Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis.
  • Tissue specificity
    Expressed in brain, spinal cord and adrenal gland.
  • Sequence similarities
    Contains 10 EGF-like domains.
    Contains 1 follistatin-like domain.
  • Cellular localization
    Cell membrane. Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region (By similarity).
  • Information by UniProt

References for Recombinant Human DNER protein (ab108954)

ab108954 has not yet been referenced specifically in any publications.

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