This product is an active protein and may elicit a biological response in vivo, handle with caution.
DNA (cytosine 5) methyltransferase 3 alpha
DNA (cytosine 5) methyltransferase 3A
DNA (cytosine-5)-methyltransferase 3A
DNA cytosine methyltransferase 3A2
DNA methyltransferase 3 alpha
DNA methyltransferase 3a
DNA methyltransferase HsaIIIA
DNA MTase HsaIIIA
Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity.
Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.