This product is an active protein and may elicit a biological response in vivo, handle with caution.
Cytosine 5 methyltransferase 3 like protein
DNA (cytosine 5 ) methyltransferase 3 like
DNA (cytosine-5)-methyltransferase 3-like
DNA cytosine 5 methyltransferase 3 like protein
DNA methyltransferase 3 like protein
Human cytosine 5 methyltransferase 3 like protein
Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3.
Expressed at low levels in several tissues including testis, ovary, and thymus.
Belongs to the C5-methyltransferase family. Contains 1 ADD-type zinc finger.