Overview

  • Product name
    Recombinant Human DOC2A protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MRGRRGDRMTINIQEHMAINVCPGPIRPIRQISDYFPRGPGPEGGGGSGG EAPAHLVPLALAPPAALLGATTPEDGAEVDSYDSDDATALGTLEFDLLYD RASCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRN TLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRR LKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQGLLE ERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVD KKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSND FIGGVSLGPGARGEARKHWSDCLQQPDAALERWHTLTSELPPAAGALSSA
    • Amino acids
      1 to 400
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab160033 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • Doc2
    • Doc2-alpha
    • Doc2a
    • DOC2A_HUMAN
    • Double C2 domain alpha
    • Double C2 like domains, alpha
    • Double C2-like domain-containing protein alpha
    see all
  • Function
    Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.
  • Tissue specificity
    Predominantly expressed in brain. Also expressed in testis.
  • Sequence similarities
    Contains 2 C2 domains.
  • Domain
    C2 domain 1 is involved in binding calcium and phospholipids.
  • Cellular localization
    Lysosome. Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Cell junction > synapse > synaptosome. Colocalizes to synaptic vesicles.
  • Information by UniProt

Images

  • ab160033 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab160033 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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