DOCK7 functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. It does not have a GEF activity for CDC42. It is required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization.
Cell projection, axon. Note=Enriched in the developing axons of hippocampal neurons.
Recombinant Human DOCK7 protein images
SDS-PAGE - DOCK7 protein (Tagged-His Tag) (ab92221)
The image shows an electrophoretic assay performed using an Agilent 5100 ALP. In some images colored control bands can be seen at 15 kDa (green) and/or 240 kDa (purple). The protein-specific band is blue.
References for Recombinant Human DOCK7 protein (ab92221)
has not yet been referenced specifically in any publications.
Publishing research using ab92221? Please let us know so that we can cite the reference in this datasheet.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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