Reconstitutionreconstitution with 69 µl aqua dest.
dedicator of cytokinesis 7
Dedicator of cytokinesis protein 7
RelevanceDOCK7 functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. It does not have a GEF activity for CDC42. It is required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization.
Cellular localizationCell projection, axon. Note=Enriched in the developing axons of hippocampal neurons.
Recombinant Human DOCK7 protein images
SDS-PAGE - DOCK7 protein (Tagged-His Tag) (ab92221)
The image shows an electrophoretic assay performed using an Agilent 5100 ALP. In some images colored control bands can be seen at 15 kDa (green) and/or 240 kDa (purple). The protein-specific band is blue.
References for Recombinant Human DOCK7 protein (ab92221)
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