Recombinant Human DOPA Decarboxylase protein (ab40029)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab40029 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5

General Info

  • Alternative names
    • AADC
    • Aromatic L Amino Acid Decarboxylase
    • Aromatic-L-amino-acid decarboxylase
    • DDC
    • DDC_HUMAN
    • DOPA decarboxylase
    • DOPA decarboxylase (aromatic L-amino acid decarboxylase)
    see all
  • FunctionCatalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
  • PathwayCatecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2.
  • Involvement in diseaseDefects in DDC are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD) [MIM:608643]. AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive.
  • Sequence similaritiesBelongs to the group II decarboxylase family.
  • Information by UniProt

Recombinant Human DOPA Decarboxylase protein images

References for Recombinant Human DOPA Decarboxylase protein (ab40029)

ab40029 has not yet been referenced specifically in any publications.

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