Recombinant Human Dopamine D2 Receptor protein (ab112281)

Overview

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionP14416
    • SpeciesHuman
    • SequenceMDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVF GNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVG EW KFSRIHCDIF
    • Molecular weight38 kDa including tags
    • Amino acids1 to 110
    • TagsGST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab112281 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityuseful for Antibody Production and Protein Array
  • Applications

    Western blot

    SDS-PAGE

    ELISA

    Peptide Array

  • FormLiquid
  • Additional notesBest use within three months from the date of receipt of this protein.useful for Antibody Production and Protein Array
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Reduced glutathione

General Info

  • Alternative names
    • D(2) dopamine receptor
    • D2 dopamine receptor
    • D2DR
    • D2R
    • Dopamine D2 receptor
    • Dopamine receptor D2
    • DRD 2
    • DRD2
    • DRD2_HUMAN
    see all
  • FunctionThis is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
  • Involvement in diseaseDefects in DRD2 are associated with dystonia type 11 (DYT11) [MIM:159900]; also known as alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.
  • Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
  • Cellular localizationCell membrane.
  • Information by UniProt

Recombinant Human Dopamine D2 Receptor protein images

  • 12.5% SDS-PAGE Stained with Coomassie Blue with recombinant protein.

References for Recombinant Human Dopamine D2 Receptor protein (ab112281)

ab112281 has not yet been referenced specifically in any publications.

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