Recombinant Human Dopamine Transporter protein (ab112352)

Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      AWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGT TPAAEYFERGVLHLHQSHGIDDLGPPR
    • Molecular weight
      34 kDa including tags
    • Amino acids
      161 to 237
    • Tags
      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab112352 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • DA transporter
    • DAT
    • DAT 1
    • DAT1
    • Dopamine transporter
    • Dopamine transporter 1
    • PKDYS
    • SC6A3_HUMAN
    • SLC6A3
    • Sodium dependent dopamine transporter
    • Sodium-dependent dopamine transporter
    • Solute carrier family 6 (neurotransmitter transporter dopamine), member 3
    • Solute carrier family 6 (neurotransmitter transporter), member 3
    • Solute carrier family 6 member 3
    • Variable number tandem repeat (VNTR)
    see all
  • Function
    Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
  • Involvement in disease
    Defects in SLC6A3 are the cause of dystonia-parkinsonism infantile (DYTPRI) [MIM:613135]. It is a neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradikinesia and pyramidal tract signs.
  • Sequence similarities
    Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.
  • Cellular localization
    Membrane.
  • Information by UniProt

Images

  • ab112352 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

References

ab112352 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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