down-regulator of transcription 1, TBP-binding (negative cofactor 2)
Negative co factor 2
Negative cofactor 2
Negative cofactor 2 beta
Negative cofactor 2-beta
TATA binding protein associated phosphoprotein
TATA box/binding protein associated phosphoprotein DR1
TATA-binding protein-associated phosphoprotein
FunctionThe association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Sequence similaritiesBelongs to the NC2 beta/DR1 family. Contains 1 histone-fold domain.
Post-translational modificationsPhosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1.