The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityDetermined by its inhibitory effect of IL8 production in Human PBMC by Human DR5. 50% inhibition (100 ng/ml of DR5) was reached using a concentration of 1000 ng/ml of DR5.
% SDS-PAGE. Purity by SDS-PAGE and HPLC is greater than 98%.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20ºC.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionReconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
Fas like protein
Apoptosis inducing protein TRICK2A/2B
Apoptosis inducing receptor TRAIL R2
Cytotoxic TRAIL receptor 2
Death domain containing receptor for TRAIL/Apo 2L
Death receptor 5
p53 regulated DNA damage inducible cell death receptor(killer)
TNF related apoptosis inducing ligand receptor 2
TNF-related apoptosis-inducing ligand receptor 2
TRAIL receptor 2
Tumor necrosis factor receptor like protein ZTNFR9
Tumor necrosis factor receptor superfamily member 10B
Tumor necrosis factor receptor superfamily, member 10b
FunctionReceptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Tissue specificityWidely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
Involvement in diseaseSquamous cell carcinoma of the head and neck
Sequence similaritiesContains 1 death domain. Contains 3 TNFR-Cys repeats.