Drosha double stranded RNA specific endoribonuclease
Drosha ribonuclease type III
Nuclear RNase III Drosha
Putative protein p241 which interacts with transcription factor Sp1
Putative ribonuclease III
Ribonuclease III nuclear
Ribonuclease type III nuclear
FunctionRibonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.
SDS-PAGE - Drosha protein (Tagged-His Tag) (ab94010)
The image shows an electrophoretic assay performed using an Agilent 5100 ALP. In some images coloured control bands can be seen at 15 kDa (green) and/or 240 kDa (purple). The protein-specific band is blue.
References for Recombinant Human Drosha protein (ab94010)
has not yet been referenced specifically in any publications.
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