Overview

  • Product nameRecombinant Human Dscam protein
  • Protein lengthProtein fragment

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionO60469
    • SpeciesHuman
    • SequenceKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDH RKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRF
    • Molecular weight35 kDa including tags
    • Amino acids184 to 271

Specifications

Our Abpromise guarantee covers the use of ab116817 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

General Info

  • Alternative names
    • CHD2
    • CHD2 42
    • CHD2 52
    • Down syndrome cell adhesion molecule
    • DSCAM
    • DSCAM_HUMAN
    • human CHD2-52 down syndrome cell adhesion molecule 2, 9
    • OTTHUMP00000109193 2
    • SD11109p
    see all
  • FunctionCell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38.
  • Tissue specificityPrimarily expressed in brain.
  • Sequence similaritiesContains 6 fibronectin type-III domains.
    Contains 10 Ig-like C2-type (immunoglobulin-like) domains.
  • DomainIg-like C2-type domains 7 to 9 are sufficient for interaction with NTN1 and commissural axon outgrowth. The transmembrane domain is necessary for interaction with DCC.
  • Post-translational
    modifications
    Phosphorylated at tyrosine residues. Phosphorylation is enhanced by netrin.
  • Cellular localizationSecreted and Cell membrane. Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons.
  • Information by UniProt

Recombinant Human Dscam protein images

  • 12.5% SDS-PAGE showing ab116817 at approximately 35.31kDa.
    Stained with Coomassie Blue.

References for Recombinant Human Dscam protein (ab116817)

ab116817 has not yet been referenced specifically in any publications.

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