The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesBest use within three months from the date of receipt of this protein.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Cytokine inducible Deubiquitinating Enzyme
Deubiquitinating enzyme 17-like protein 2
Deubiquitinating enzyme 3
Deubiquitinating protein 3
Ubiquitin carboxyl-terminal hydrolase 17-like protein 2
Ubiquitin thiolesterase 17-like protein 2
Ubiquitin-specific-processing protease 17-like protein 2
FunctionDeubiquitinating enzyme that specifically removes conjugated ubiquitin from CDC25A, thereby playing a key role in cell cycle regulation. Deubiquitination of CDC25A prevents its degradation by the proteasome during the G1/S and G2/M phases of the cell cycle and is required for cell-cycle progression. Has transforming capabilities on cell lines. May also function in cell apoptosis.
Tissue specificityBroadly expressed.
Sequence similaritiesBelongs to the peptidase C19 family. USP17 subfamily.