Recombinant Human DUSP26 protein (denatured) (ab171697)

Overview

  • Product name
    Recombinant Human DUSP26 protein (denatured)
  • Protein length
    Full length protein
  • Description
    Recombinant Human DUSP26 protein

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGSMCPGNWL WASMTFMARF SRSSSRSPVR TRGTLEEMPT VQHPFLNVFE LERLLYTGKT ACNHADEVWP GLYLGDQDMA NNRRELRRLG ITHVLNASHS RWRGTPEAYE GLGIRYLGVE AHDSPAFDMS IHFQTAADFI HRALSQPGGK ILVHCAVGVS RSATLVLAYL MLYHHLTLVE AIKKVKDHRG IIPNRGFLRQ LLALDRRLRQ GLEA
    • Molecular weight
      26 kDa
    • Amino acids
      1 to 211
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab171697 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 85 % SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 2.4% Urea, 0.32% Tris HCl, 10% Glycerol

General Info

  • Alternative names
    • DSP-4
    • Dual specificity phosphatase 26
    • Dual specificity phosphatase 26 (putative)
    • Dual specificity phosphatase SKRP3
    • Dual specificity protein phosphatase 26
    • DUS26_HUMAN
    • DUSP24
    • DUSP26
    • Hypothetical protein FLJ31142
    • LDP 4
    • LDP-4
    • Low molecular mass dual specificity phosphatase 4
    • Low-molecular-mass dual-specificity phosphatase 4
    • MAP kinase phosphatase 8
    • MGC1136
    • MGC2627
    • Mitogen activated protein kinase phosphatase 8
    • Mitogen-activated protein kinase phosphatase 8
    • MKP-8
    • MKP8
    • NATA1
    • NATA1 protein
    • Novel amplified gene in thyroid anaplastic cancer
    • SKRP3
    see all
  • Function
    Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).
  • Tissue specificity
    Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.
  • Sequence similarities
    Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
    Contains 1 tyrosine-protein phosphatase domain.
  • Cellular localization
    Cytoplasm. Nucleus. Golgi apparatus.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab171697 (3 µg).

References

ab171697 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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