Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human

Specifications

Our Abpromise guarantee covers the use of ab90613 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Specific activity: 1 nmol of Cdc25A will hydrolyze 180 nmol of pNPP per minute at 37°C at pH 6.5. Assay buffer: 25 mM MOPS, pH 6.5 and 5 mM EDTA.
  • Applications

    Functional Studies

    SDS-PAGE

  • Purity
    > 90 % SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50mM HEPES, 40mM Sodium chloride, 1mM EDTA, 1mM DTT, pH 7.4

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • Dual specificity phosphatase 3
    • Dual specificity protein phosphatase 3
    • Dual specificity protein phosphatase VHR
    • DUS3_HUMAN
    • DUSP3
    • Serine/threonine specific protein phosphatase
    • Vaccinia H1-related phosphatase
    • Vaccinia virus phosphatase VH1 related
    • VHR
    see all
  • Function
    Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.
  • Sequence similarities
    Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
    Contains 1 tyrosine-protein phosphatase domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt

References

ab90613 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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