The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Axonemal dynein intermediate chain 1
Axonemal dynein intermediate chain 2
Cytoplasmic dynein 1 intermediate chain 1
Cytoplasmic dynein 1 intermediate chain 2
Cytoplasmic dynein intermediate chain 1
Cytoplasmic dynein intermediate chain 2
DH IC 1
DH IC 2
Dynein axonemal intermediate chain 1
Dynein axonemal intermediate polypeptide 1
Dynein axonemal intermediate polypeptide 2
Dynein cytoplasmic intermediate polypeptide 1
Dynein cytoplasmic intermediate polypeptide 2
Dynein intermediate chain 1 axonemal
Dynein intermediate chain 1 cytosolic
Dynein intermediate chain 1, axonemal
Dynein intermediate chain 2 axonemal
Dynein intermediate chain 2 cytosolic
Dynein intermediate chain DNAI1
Immotile cilia syndrome 1
Part of the dynein complex of respiratory cilia.
Involvement in disease
Defects in DNAI1 are the cause of primary ciliary dyskinesia type 1 (CILD1) [MIM:244400]. CILD1 is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Defects in DNAI1 are the cause of Kartagener syndrome (KTGS) [MIM:244400]. KTGS is an autosomal recessive disorder characterized by the association of primary ciliary dyskinesia with situs inversus. Clinical features include recurrent respiratory infections, bronchiectasis, infertility, and lateral transposition of the viscera of the thorax and abdomen. The situs inversus is most often total, although it can be partial in some cases (isolated dextrocardia or isolated transposition of abdominal viscera).
Belongs to the dynein intermediate chain family. Contains 5 WD repeats.
ab153279 on a 12.5% SDS-PAGE stained with Coomassie Blue.
This product has been referenced in:
Calderilla-Barbosa L et al. Interaction of SQSTM1 with the motor protein dynein--SQSTM1 is required for normal dynein function and trafficking. J Cell Sci127:4052-63 (2014).
Read more (PubMed: 25015291) »