Recombinant Human Dynein intermediate chain 2 protein (ab163843)

Overview

  • Product name
    Recombinant Human Dynein intermediate chain 2 protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MEIVYVYVKKRSEFGKQCNFSDRQAELNIDIMPNPELAEQFVERNPVDTG IQCSISMSEHEANSERFEMETRGVNHVEGGWPKDVNPLELEQTIRFRKKV EKDENYVNAIMQLGSIMEHCIKQNNAIDIYEEYFNDEEAMEVMEEDPSAK TINVFRDPQEIKRAATHLSWHPDGNRKLAVAYSCLDFQRAPVGMSSDSYI WDLENPNKPELALKPSSPLVTLEFNPKDSHVLLGGCYNGQIACWDTRKGS LVAELSTIESSHRDPVYGTIWLQSKTGTECFSASTDGQVMWWDIRKMSEP TEVVILDITKKEQLENALGAISLEFESTLPTKFMVGTEQGIVISCNRKAK TSAEKIVCTFPGHHGPIYALQRNPFYPKNFLTVGDWTARIWSEDSRESSI MWTKYHMAYLTDAAWSPVRPTVFFTTRMDGTLDIWDFMFEQCDPTLSLKD NGCLIACGSQLGTTTLLEVSPGLSTLQRNEKNVASSMFERETRREKILEA RHREMRLKEKGKAEGRDEEQTDEELAVDLEALVSKAEEEFFDIIFTELKK KEADAIKLTPVPQQPSPEEDQVVEEGEEAAGEEGDEEVEEDLA
    • Amino acids
      1 to 593
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab163843 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • axonemal
    • Axonemal dynein intermediate chain 2
    • CILD9
    • DNAI 2
    • Dnai2
    • DNAI2_HUMAN
    • Dynein axonemal intermediate chain 2
    • Dynein axonemal intermediate polypeptide 2
    • Dynein intermediate chain 2
    • Dynein intermediate chain 2 axonemal
    see all
  • Function
    Part of the dynein complex of respiratory cilia.
  • Tissue specificity
    Highly expressed in trachea and testis.
  • Involvement in disease
    Defects in DNAI2 are the cause of primary ciliary dyskinesia type 9 (CILD9) [MIM:612444]. CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
  • Sequence similarities
    Belongs to the dynein intermediate chain family.
    Contains 5 WD repeats.
  • Cellular localization
    Cytoplasm > cytoskeleton > cilium axoneme.
  • Information by UniProt

Images

  • ab163843 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

This product has been referenced in:
  • Calderilla-Barbosa L  et al. Interaction of SQSTM1 with the motor protein dynein--SQSTM1 is required for normal dynein function and trafficking. J Cell Sci 127:4052-63 (2014). Read more (PubMed: 25015291) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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