Recombinant Human Dystonin protein (ab117061)

Overview

  • Product nameRecombinant Human Dystonin protein
  • Protein lengthProtein fragment

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionQ03001
    • SpeciesHuman
    • SequenceEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQI LIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMIS
    • Molecular weight37 kDa including tags
    • Amino acids401 to 500

Associated products

Specifications

Our Abpromise guarantee covers the use of ab117061 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

    ELISA

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • 230 kDa bullous pemphigoid antigen
    • 230/240 kDa bullous pemphigoid antigen
    • BP230
    • BP240
    • BPA
    • BPAG1
    • Bullous pemphigoid antigen
    • Bullous pemphigoid antigen 1
    • DMH
    • DST
    • DT
    • Dystonia musculorum protein
    • Hemidesmosomal plaque protein
    • KIAA0728
    see all
  • RelevanceCytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Isoform 3: plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity. Isoform 6: required for bundling actin filaments around the nucleus By similarity. Isoform 7: regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.
  • Cellular localizationCytoplasm › cytoskeleton.

Recombinant Human Dystonin protein images

  • 12.5% SDS-PAGE showing ab117061 at approximately 36.63 kDa.
    Stained with Coomassie Blue.

References for Recombinant Human Dystonin protein (ab117061)

ab117061 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"