Recombinant human Dystrophia myotonica protein kinase (ab85755)



  • NatureRecombinant
  • SourceBaculovirus infected Sf9 cells
  • Amino Acid Sequence
    • SpeciesHuman

Associated products


Our Abpromise guarantee covers the use of ab85755 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThe Specific activity of ab85755 was determined to be 4.5 nmol/min/mg.
  • Applications

    Western blot

    Functional Studies


  • FormLiquid
  • Additional notes

    ab204853 (IRS1 peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • DM
    • DM 1
    • DM kinase
    • DM protein kinase
    • DM-kinase
    • DM1
    • DM1 protein kinase
    • DM1PK
    • DMK
    • DMPK
    • Dystrophia myotonica 1
    • Dystrophia myotonica protein kinase
    • MDPK
    • MT PK
    • MT-PK
    • Myotonic dystrophy associated protein kinase
    • Myotonic dystrophy protein kinase
    • Myotonin protein kinase
    • Myotonin protein kinase A
    • Myotonin-protein kinase
    • Thymopoietin homolog
    see all
  • FunctionCritical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity. Phosphorylates phospholamban.
  • Tissue specificityMost isoforms are expressed in many tissues including heart, skeletal muscle, liver and brain, except for isoform 2 which is only found in the heart and skeletal muscle, and isoform 14 which is only found in the brain, with high levels in the striatum, cerebellar cortex and pons.
  • Involvement in diseaseDefects in DMPK are the cause of dystrophia myotonica type 1 (DM1) [MIM:160900]; also known as Steinert disease. A muscular disorder characterized by myotonia, muscle wasting in the distal extremities, cataract, hypogonadism, defective endocrine functions, male baldness and cardiac arrhythmias. Note=The causative mutation is a CTG expansion in the 3'-UTR of the DMPK gene. A length exceeding 50 CTG repeats is pathogenic, while normal individuals have 5 to 37 repeats. Intermediate alleles with 35-49 triplets are not disease-causing but show instability in intergenerational transmissions. Disease severity varies with the number of repeats: mildly affected persons have 50 to 150 repeats, patients with classic DM have 100 to 1,000 repeats, and those with congenital onset can have more than 2,000 repeats.
  • Sequence similaritiesBelongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 protein kinase domain.
  • Information by UniProt

Recombinant human Dystrophia myotonica protein kinase images

  • The Specific activity of ab85755 was determined to be 4.5 nmol/min/mg.
  • SDS-PAGE showing ab85755 at approximately 105kDa.

References for Recombinant human Dystrophia myotonica protein kinase (ab85755)

ab85755 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab85755.
Please use the links above to contact us or submit feedback about this product.