Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      VRVTAADAFLDLIRNMFPPNLVEACFKQFKTNYEKRSFKVPIQANETLVG AVINNVSEAMETLTRITEELVPVPGS
    • Molecular weight
      34 kDa including tags
    • Amino acids
      162 to 237

Specifications

Our Abpromise guarantee covers the use of ab114209 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • EA6
    • EAA1_HUMAN
    • EAAT1
    • Excitatory amino acid transporter 1
    • FLJ25094
    • GLAST
    • GLAST-1
    • GLAST1
    • Glial high affinity glutamate transporter
    • glutamate/aspartate transporter, high affinity, sodium-dependent
    • High affinity neuronal glutamate transporter
    • Slc1a3
    • Sodium dependent glutamate/aspartate transporter
    • Sodium-dependent glutamate/aspartate transporter 1
    • Solute carrier family 1 (glial high affinity glutamate transporter) member 3
    • Solute carrier family 1 member 3
    see all
  • Function
    Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
  • Tissue specificity
    Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia.
  • Involvement in disease
    Defects in SLC1A3 are the cause of episodic ataxia type 6 (EA6) [MIM:612656]. EA6 is characterized by episodic ataxia, seizures, migraine and alternating hemiplegia.
  • Sequence similarities
    Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A3 subfamily.
  • Post-translational
    modifications
    Glycosylated.
  • Cellular localization
    Membrane.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE analysis of ab114209 stained with Coomassie Blue.

References

ab114209 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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