The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. Purity is greater than 80% as determined by SDS-PAGE.
Endotoxin level is < 0.01 ng per µg of rhEBI3.
Additional notesEndotoxin Level: <0.01 ng/µg.
Assay data for human recombinant EBI3 is based upon qualitative binding to anti-EBI3 antibody.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20ºC.
ReconstitutionWhen reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 – 0.5 mg/ml, which can be further diluted into other aqueous solutions.
EBV induced gene 3 protein
EBV-induced gene 3 protein
Epstein Barr virus induced 3
Epstein Barr virus induced gene 3
Epstein Barr virus induced gene 3 protein
Epstein-Barr virus-induced gene 3 protein
IL 27 subunit beta
IL-27 subunit beta
IL27 subunit beta
interleukin 27 subunit beta
Interleukin-27 subunit beta
FunctionAssociates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
Sequence similaritiesBelongs to the type I cytokine receptor family. Type 3 subfamily. Contains 2 fibronectin type-III domains.