Endothelial differentiation sphingolipid G protein coupled receptor 3
G protein coupled receptor endothelial differentiation gene 3
S1P receptor 3
S1P receptor Edg 3
S1P receptor Edg-3
S1P receptor EDG3
Sphingosine 1 phosphate receptor 3
Sphingosine 1 phosphate receptor Edg 3
Sphingosine 1 phosphate receptor Edg3
Sphingosine 1-phosphate receptor 3
Sphingosine 1-phosphate receptor Edg-3
FunctionReceptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
Tissue specificityExpressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.