The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityUseful for Antibody Production and Protein Array
Additional notesab112381 is best used within three months from the date of receipt.Useful for Antibody Production and Protein Array
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.79% Tris HCl, 0.31% Glutathione Note: Glutathione is reduced
EED, mouse, homolog of
Embryonic ectoderm development
Embryonic ectoderm development isoform a
Embryonic ECTODERM development protein homolog
Embryonic ectoderm development protein, mouse, homolog of
Polycomb protein eed
WD protein associating with integrin cytoplasmic tails 1
FunctionPolycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
Tissue specificityExpressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus. Appears to be overexpressed in breast and colon cancer.
Sequence similaritiesBelongs to the WD repeat ESC family. Contains 7 WD repeats.
Developmental stageExpression peaks at the G1/S phase boundary.
Cellular localizationNucleus. Chromosome. Transiently colocalizes with XIST at inactive X chromosomes.