This product is an active protein and may elicit a biological response in vivo, handle with caution.
Ankyrin repeat containing protein
Euchromatic histone lysine N methyltransferase 2
Euchromatic histone-lysine N-methyltransferase 2
G9A histone methyltransferase
H3 K9 HMTase 3
Histone H3 K9 methyltransferase 3
Histone H3 K9 methyltransferase3
Histone H3-K9 methyltransferase 3
Histone lysine N methyltransferase
Histone lysine N methyltransferase EHMT2
Histone lysine N methyltransferase, H3 lysine 9 specific 3
Histone lysine N methyltransferase, H3 lysine 9 specific3
Histone-lysine N-methyltransferase EHMT2
HLA B associated transcript 8
HLA-B-associated transcript 8
Lysine N methyltransferase 1C
Lysine N-methyltransferase 1C
FunctionHistone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.
Tissue specificityExpressed in all tissues examined, with high levels in fetal liver, thymus, lymph node, spleen and peripheral blood leukocytes and lower level in bone marrow.
Sequence similaritiesBelongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. Contains 7 ANK repeats. Contains 1 post-SET domain. Contains 1 pre-SET domain. Contains 1 SET domain.
DomainThe SET domain mediates interaction with WIZ. The ANK repeats bind H3K9me1 and H3K9me2.
Post-translational modificationsMethylated at Lys-185; automethylated.
Cellular localizationNucleus. Chromosome. Associates with euchromatic regions. Does not associate with heterochromatin.