Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      VLKLYQFNPAFFQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQ
    • Amino acids
      50 to 94

Specifications

Our Abpromise guarantee covers the use of ab80036 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

    SDS-PAGE

  • Purity
    > 90 % SDS-PAGE.

  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: PBS

  • Reconstitution
    Redissolve the powder with 1ml sterile water will restore to the original concentration 1mg/ml.

General Info

  • Alternative names
    • ARG134
    • eIF 3 p25
    • eIF 3 p28
    • eIF-3 p25
    • eIF-3 p28
    • EIF3-p28
    • eif3k
    • EIF3K_HUMAN
    • EIF3S12
    • Eukaryotic translation initiation factor 3 subunit 12
    • Eukaryotic translation initiation factor 3 subunit K
    • HSPC029
    • M9
    • MSTP001
    • Muscle specific gene M9 protein
    • Muscle-specific gene M9 protein
    • PLAC 24
    • PLAC-24
    • PLAC24
    • PRO1474
    • PTD001
    see all
  • Function
    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
  • Tissue specificity
    Ubiquitous, with the highest levels of expression in brain, testis and kidney.
  • Sequence similarities
    Belongs to the eIF-3 subunit K family.
  • Cellular localization
    Nucleus. Cytoplasm.
  • Information by UniProt

Images

  • 20% SDS PAGE gel, Commassie blue staining.

References

ab80036 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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