Recombinant Human eIF4EBP1 protein (ab85248)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Additional sequence information
      This protein has a GST tag.

Specifications

Our Abpromise guarantee covers the use of ab85248 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5

General Info

  • Alternative names
    • 4E-BP1
    • 4EBP1
    • 4EBP1_HUMAN
    • BP 1
    • eIF4E binding protein 1
    • eIF4E-binding protein 1
    • Eif4ebp1
    • Eukaryotic translation initiation factor 4E-binding protein 1
    • PHAS-I
    • PHASI
    • Phosphorylated heat- and acid-stable protein regulated by insulin 1
    see all
  • Function
    Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
  • Sequence similarities
    Belongs to the eIF4E-binding protein family.
  • Post-translational
    modifications
    Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70 is regulated by mTORC1. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Information by UniProt

Images

  • SDS-PAGE showing ab85248 at approximately 40kDa.

References

ab85248 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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