The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesProtein concentration is above or equal to 0.05 mg/ml. Best use within three months from the date of receipt of this protein.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
E74 like factor 5
E74 like factor 5 (ets domain transcription factor)
E74-like factor 5
Epithelium restricted ESE 1 related Ets factor
Epithelium restricted ESE1 related Ets factor
Epithelium specific Ets transcription factor 2
Epithelium-restricted ESE-1-related Ets factor
Epithelium-specific Ets transcription factor 2
Ets domain TF
Ets domain transcription factor
ETS related transcription factor Elf 5
ETS related transcription factor Elf5
ETS-related transcription factor Elf-5
FunctionTranscriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters.
Tissue specificityExpressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, kidney and prostate. Weakly expressed in placenta and lung. Isoform 1 and isoform 2 are differentially expressed in different tissues. In the kidney, only isoform 1 was expressed, while prostate expressed both isoforms, with levels of isoform 2 being higher. Expression is up-regulated during keratinocyte differentiation. Several epithelial carcinoma cell lines showed lack of expression.
Sequence similaritiesBelongs to the ETS family. Contains 1 ETS DNA-binding domain. Contains 1 PNT (pointed) domain.
DomainThe PNT domain acts as a transcriptional activator.