The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Crossover junction endonuclease EME1
Eme1 essential meiotic endonuclease 1 homolog 1 (S. pombe)
EME1, S. pombe, homolog of, 1
Essential Meiotic Endonuclease 1 Homolog 1
essential meiotic endonuclease 1 homolog 1 (S pombe)
essential meiotic endonuclease 1 homolog 2
Essential meiotic endonuclease 1, S. pombe, homolog of, 1
homolog of yeast EME1 endonuclease
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.
Belongs to the EME1/MMS4 family.
Nucleus > nucleolus. Recruited to regions of DNA damage in S-phase cells.