The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. Greater than 98% as determined by SDS-PAGE and HPLC.
For long-term storage, aliquot and keep desiccated below –20degC. Avoid freeze-thaw cycles.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Endotoxin level is less than 0.1 ng/mg of Endostatin
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Alpha 1 collagen type 18 (XVIII)(COL18A1)
Alpha 1 type XVIII collagen
Collagen alpha 1(XV) chain
Collagen alpha 1(XVIII) chain
Collagen alpha-1(XV) chain
Collagen type XV proteoglycan
Collagen type XVIII alpha 1
Collagen XV, alpha 1 polypeptide
Collagen, type XV, alpha 1
Multi functional protein MFP
COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
Present in multiple organs with highest levels in liver, lung and kidney.
Involvement in disease
Defects in COL18A1 are a cause of Knobloch syndrome (KNO) [MIM:267750]. KNO is an autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.
Belongs to the multiplexin collagen family. Contains 1 FZ (frizzled) domain. Contains 1 TSP N-terminal (TSPN) domain.
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Secreted > extracellular space > extracellular matrix.