Recombinant human Endostatin protein (ab73653)

Overview

Description

  • NatureRecombinant
  • SourcePichia pastoris
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceAmino Acid Composition is in total agreement with the expected amino acid composition of native human Endostatin.

Specifications

Our Abpromise guarantee covers the use of ab73653 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThe activity calculated by ECE migration inhibition was found to be 50,000IU/mg.
  • Applications

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.
    ab73653 is purified by proprietary chromatographic techniques. Purity is greater than 98.0% as determined by RP-HPLC and SDS-PAGE.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: PBS

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • Alpha 1 collagen type 18 (XVIII)(COL18A1)
    • Alpha 1 type XVIII collagen
    • Antiangiogenic agent
    • COIA1_HUMAN
    • COL15A1
    • Col18a1
    • Collagen alpha 1(XV) chain
    • Collagen alpha 1(XVIII) chain
    • Collagen alpha-1(XV) chain
    • Collagen type XV proteoglycan
    • Collagen type XVIII alpha 1
    • Collagen XV, alpha 1 polypeptide
    • Collagen, type XV, alpha 1
    • Endostatin
    • Endostatin XV
    • FLJ27325
    • FLJ34914
    • FLJ38566
    • KNO
    • KNO1
    • KS
    • MGC74745
    • Multi functional protein MFP
    • OTTHUMP00000021782
    • OTTHUMP00000115472
    • OTTHUMP00000115473
    see all
  • FunctionCOLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.
    Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
  • Tissue specificityPresent in multiple organs with highest levels in liver, lung and kidney.
  • Involvement in diseaseDefects in COL18A1 are a cause of Knobloch syndrome (KNO) [MIM:267750]. KNO is an autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.
  • Sequence similaritiesBelongs to the multiplexin collagen family.
    Contains 1 FZ (frizzled) domain.
    Contains 1 TSP N-terminal (TSPN) domain.
  • Post-translational
    modifications
    Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.
  • Information by UniProt

References for Recombinant human Endostatin protein (ab73653)

ab73653 has not yet been referenced specifically in any publications.

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