Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      KGLHLSSTTPTALVHTSPSTAGSALLQPSNITQTSSSHSALSHQVTAANS ATTQVLIGNNIRLTVPSSVATVNSIAPINARHIPRTLSAVPSSALKLAAA ANCQ
    • Amino acids
      695 to 798
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab164249 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • DKFZp781P2312
    • Enhancer of polycomb 1
    • Enhancer of polycomb homolog 1
    • Enhancer of polycomb homolog 1 (Drosophila)
    • EPC1
    • EPC1_HUMAN
    • Epl 1
    • Epl1
    • OTTHUMP00000046260
    see all
  • Function
    Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.
  • Sequence similarities
    Belongs to the enhancer of polycomb family.
  • Cellular localization
    Nucleus.
  • Information by UniProt

Images

  • ab164249 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab164249 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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