Recombinant Human Estrogen Related Receptor gamma protein (ab114455)

Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSST MNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLN SMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECE ITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPY LNPQLVQPAKKPLLWSDPADNKIVSHLLVAEPEKIYAMPDPTAPDSDIKA LTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVV YRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKE EFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRA GKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLLLEMLEAKV
    • Molecular weight
      75 kDa including tags
    • Amino acids
      1 to 442

Specifications

Our Abpromise guarantee covers the use of ab114455 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

    SDS-PAGE

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
    ab114455 is best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

General Info

  • Alternative names
    • DKFZp781L1617
    • ERR 3
    • ERR G2
    • ERR gamma 2
    • ERR gamma-2
    • ERR3
    • ERR3_HUMAN
    • ERRG 2
    • ERRG2
    • ERRgamma
    • ESRRG
    • Estrogen receptor related protein 3
    • Estrogen receptor-related protein 3
    • Estrogen-related receptor gamma
    • FLJ16023
    • KIAA0832
    • NR3B3
    • Nuclear receptor subfamily 3 group B member 3
    see all
  • Function
    Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements.
  • Tissue specificity
    Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland.
  • Sequence similarities
    Belongs to the nuclear hormone receptor family. NR3 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Developmental stage
    Expressed at high levels in fetal brain and also in the fetal kidney, lung and liver.
  • Post-translational
    modifications
    Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.
    Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.
  • Cellular localization
    Nucleus.
  • Information by UniProt

Images

  • ab114455 analysed on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab114455 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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