Recombinant Human EXOSC10 protein (ab73483)



  • NatureRecombinant
  • SourceBaculovirus infected Sf9 cells
  • Amino Acid Sequence
    • SpeciesHuman

Associated products


Our Abpromise guarantee covers the use of ab73483 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThis protein binds IgG-type human auto-antibodies and polymyositis patient sera.
  • Applications

    Western blot


  • FormLiquid
  • Additional notes

    This protein is suitable for biotinylation and iodination.

    This protein binds IgG-type human auto-antibodies and polymyositis patient sera.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 0.02% SDS, 20mM HEPES, 100mM Sodium chloride, 0.01mM EDTA, pH 7.5

General Info

  • Alternative names
    • Autoantigen PM/Scl 2
    • Exosc10
    • Exosome component 10
    • P100 polymyositis scleroderma overlap syndrome associated autoantigen
    • P100 polymyositis-scleroderma overlap syndrome-associated autoantigen
    • p2
    • p3
    • p4
    • PM Scl
    • PM/Scl 100
    • PM/Scl-100
    • PMSCL
    • PMSCL2
    • Polymyositis/scleroderma autoantigen 100 kDa
    • Polymyositis/scleroderma autoantigen 2
    • Polymyositis/scleroderma autoantigen 2 100 kDa
    • RRP6
    • Rrp6p
    see all
  • FunctionPutative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.
  • Sequence similaritiesContains 1 3'-5' exonuclease domain.
    Contains 1 HRDC domain.
  • Cellular localizationCytoplasm. Nucleus, nucleolus. Nucleus. Strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form.
  • Information by UniProt

References for Recombinant Human EXOSC10 protein (ab73483)

ab73483 has not yet been referenced specifically in any publications.

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