ReconstitutionAdd deionized water (200 µl) to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve
completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Fatty acid binding protein 6, ileal (gastrotropin)
Fatty acid-binding protein 6
Ileal lipid binding protein
Ileal lipid-binding protein
Intestinal 15 kDa protein
Intestinal bile acid binding protein
Intestinal bile acid-binding protein
FunctionIleal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis.
Tissue specificityIsoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is expressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum.
Sequence similaritiesBelongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
DomainForms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
Cellular localizationCytoplasm and Cytoplasm. Localized close to nucleus on the apical side of both normal and neoplastic cells.