Fatty acid binding protein 6, ileal (gastrotropin)
Fatty acid-binding protein 6
Ileal lipid binding protein
Ileal lipid-binding protein
Intestinal 15 kDa protein
Intestinal bile acid binding protein
Intestinal bile acid-binding protein
FunctionIleal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis.
Tissue specificityIsoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is expressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum.
Sequence similaritiesBelongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
DomainForms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
Cellular localizationCytoplasm and Cytoplasm. Localized close to nucleus on the apical side of both normal and neoplastic cells.