Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MKHHHHHHAS ELIPDAPLSS AAYSIRSIGE RPVLKAPVPK RQKCDHWTPC PSDTYAYRLL SGGGRSKYAK ICFEDNLLMG EQLGNVARGI NIAIVNYVTG NVTATRCFDM YEGDNSGPMT KFIQSAAPKS LLFMVTYDDG STRLNNDAKN AIEALGSKEI RNMKFRSSWV FIAAKGLELP SEIQREKINH SDAKNNRYSG WPAEIQIEGC IPKERS
    • Molecular weight
      24 kDa including tags
    • Amino acids
      30 to 235
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab113864 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

    ELISA

  • Endotoxin level
    < 1.000 Eu/µg
  • Purity
    > 90 % SDS-PAGE.

  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.24% Tris, 0.29% Sodium chloride

  • Reconstitution
    Add deionized water (200 µl) to prepare a working stock solution of 0.5 mg/mL

General Info

  • Alternative names
    • 2-21
    • C21orf11
    • C21orf76
    • Cytokine like protein 2 21
    • Cytokine-like protein 2-21
    • Fam3b
    • FAM3B_HUMAN
    • Family with sequence similarity 3 member B
    • ORF9
    • Pancreatic-derived factor
    • PANDER
    • PRED44
    • Protein FAM3B
    see all
  • Function
    Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner. Present in insulin secretory granules and likely cosecreted with insulin.
  • Tissue specificity
    Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis.
  • Sequence similarities
    Belongs to the FAM3 family.
  • Post-translational
    modifications
    2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46.
  • Cellular localization
    Secreted. Localized in discrete vesicular and perinuclear structure.
  • Information by UniProt

Images

  • 12% SDS-PAGE separation of Human FAM3B
    1. reduced and heated sample, 5µg/lane
    2. non-reduced and non-heated sample, 5µg/lane

References

ab113864 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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