Overview

  • Product name
    Recombinant Human FANCG protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MSRQTTSVGSSCLDLWREKNDRLVRQAKVAQNSGLTLRRQQLAQDALE GLRGLLHSLQGLPAAVPVLPLELTVTCNFIILRASLAQGFTEDQAQDIQR SLERVLETQEQQGPRLEQGLRELWDSVLRASCLLPELLSALHRLVGLQAA LWLSADRLGDLALLLETLNGSQSGASKDLLLLLKTWSPPAEELDAPLTLQ DAQGLKDVLLTAFAYRQGLQELITGNPDKALSSLHEAASGLCPRPVLVQV YTALGSCHRKMGNPQRALLYLVAALKEGSAWGPPLLEASRLYQQLGDTTA ELESLELLVEALNVPCSSKAPQFLIEVELLLPPPDLASPLHCGTQSQTKH ILASRCLQTGRAGDAAEHYLDLLALLLDSSEPRFSPPPSPPGPCMPEVFL EAAVALIQAGRAQDALTLCEELLSRTSSLLPKMSRLWEDARKGTKELPYC PLWVSATHLLQGQAWVQLGAQKVAISEFSRCLELLFRATPEEKEQGAAFN CEQGCKSDAALQQLRAAALISRGLEWVASGQDTKALQDFLLSVQMCPGNR DTYFHLLQTLKRLDRRDEATALWWRLEAQTKGSHEDALWSLPLYLESYLS WIRPSDRDAFLEEFRTSLPKSCDL
    • Molecular weight
      95 kDa including tags
    • Amino acids
      1 to 622

Specifications

Our Abpromise guarantee covers the use of ab114925 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

General Info

  • Alternative names
    • DNA repair protein XRCC9
    • FAG
    • FANCG
    • FANCG_HUMAN
    • Fanconi anaemia complementation group G
    • Fanconi anemia group G protein
    • Protein FACG
    • X ray repair, complementing defective, in Chinese hamster cells 9
    • X-ray repair, complementing defective, in Chinese hamster, 9
    • XRCC9
    see all
  • Function
    DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.
  • Tissue specificity
    Highly expressed in testis and thymus. Found in lymphoblasts.
  • Involvement in disease
    Defects in FANCG are a cause of Fanconi anemia (FA) [MIM:227650]. FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.
  • Sequence similarities
    Contains 4 TPR repeats.
  • Cellular localization
    Nucleus. Cytoplasm. The major form is nuclear. The minor form is cytoplasmic.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE showing ab114925 at approximately 94.53kDa.
    Stained with Coomassie Blue.

References

ab114925 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab114925.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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