Overview

  • Product nameRecombinant Human Fascin protein
  • Protein lengthFull length protein

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ16658
    • SpeciesHuman
    • SequenceMGSSHHHHHH SSGLVPRGSH MTANGTAEAV QIQFGLINCG NKYLTAEAFG FKVNASASSL KKKQIWTLEQ PPDEAGSAAV CLRSHLGRYL AADKDGNVTC EREVPGPDCR FLIVAHDDGR WSLQSEAHRR YFGGTEDRLS CFAQTVSPAE KWSVHIAMHP QVNIYSVTRK RYAHLSARPA DEIAVDRDVP WGVDSLITLA FQDQRYSVQT ADHRFLRHDG RLVARPEPAT GYTLEFRSGK VAFRDCEGRY LAPSGPSGTL KAGKATKVGK DELFALEQSC AQVVLQAANE RNVSTRQGMD LSANQDEETD QETFQLEIDR DTKKCAFRTH TGKYWTLTAT GGVQSTASSK NASCYFDIEW RDRRITLRAS NGKFVTSKKN GQLAASVETA GDSELFLMKL INRPIIVFRG EHGFIGCRKV TGTLDANRSS YDVFQLEFND GAYNIKDSTG KYWTVGSDSA VTSSGDTPVD FFFEFCDYNK VAIKVGGRYL KGDHAGVLKA SAETVDPASL WEY
    • Molecular weight57 kDa including tags
    • Amino acids1 to 493
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab99240 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.
    ab99240 is purified using conventional chromatography techniques.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris HCl, 2mM DTT, 100mM Sodium chloride, pH 8.0

General Info

  • Alternative names
    • 55 kDa actin bundling protein
    • 55 kDa actin-bundling protein
    • Actin bundling protein
    • actin bundling protein, 55-KD
    • FAN 1
    • FAN1
    • Fascin
    • Fascin 1
    • Fascin actin bundling protein 1
    • Fascin homolog 1
    • Fascin homolog 1 actin bundling protein (Strongylocentrotus purpuratus)
    • Fascin, sea urchin, homolog of, 1
    • Fascin1
    • FLJ38511
    • FSCN 1
    • FSCN1
    • FSCN1_HUMAN
    • HSN
    • p55
    • Singed (Drosophila) like (sea urchin fascin homolog like)
    • Singed drosophila homolog like
    • Singed like (fascin homolog sea urchin)
    • Singed like (fascin homolog sea urchin) (Drosophila)
    • Singed like protein
    • Singed, drosophila, homolog of
    • Singed-like protein
    • SNL
    • Strongylocentrotus purpuratus
    see all
  • FunctionOrganizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.
  • Tissue specificityUbiquitous.
  • Sequence similaritiesBelongs to the fascin family.
  • DomainComposed of four beta-trefoil domains.
  • Post-translational
    modifications
    Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin.
  • Cellular localizationCytoplasm > cytoskeleton. Cell projection > filopodium. Cell projection > invadopodium.
  • Information by UniProt

Recombinant Human Fascin protein images

  • 15% SDS-PAGE showing ab99240 at approximately 56.7kDa (3µg).

References for Recombinant Human Fascin protein (ab99240)

ab99240 has not yet been referenced specifically in any publications.

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