The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Fatty acid coenzyme A ligase, very long chain 1
Fatty acid transport protein 2
Fatty-acid-coenzyme A ligase
Long chain fatty acid CoA ligase
Solute carrier family 27 (fatty acid transporter), member 2
Solute carrier family 27 member 2
THCA CoA ligase
Very long chain acyl CoA synthetase
Very long chain fatty acid CoA ligase
Very long chain fatty acid coenzyme A ligase 1
very long-chain 1
Very long-chain acyl-CoA synthetase
Very long-chain-fatty-acid-CoA ligase
Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes.
Expressed in liver, kidney, placenta and pancreas.
Belongs to the ATP-dependent AMP-binding enzyme family.
Endoplasmic reticulum membrane. Peroxisome membrane. Peripheral membrane associated with the lumenal side of peroxisomes.