For the best experience on the Abcam website please upgrade to a modern browser such as Google Chrome
Recombinant Human FBXO25 protein
Full length protein
Amino Acid Sequence
MPFLGQDWRSPGWSWIKTEDGWKRCESCSQKLERENNHCNISHSIILNSE DGEIFNNEEHEYASKKRKKDHFRNDTNTQSFYREKWIYVHKESTKERHGY CTLGEAFNRLDFSSAIQDIRRFNYVVKLLQLIAKSQLTSLSGVAQKNYFN ILDKIVQKVLDDHHNPRLIKDLLQDLSSTLCILIRGVGKSVLVGNINIWI CRLETILAWQQQLQDLQMTKQVNNGLTLSDLPLHMLNNILYRFSDGWDII TLGQVTPTLYMLSEDRQLWKKLCQYHFAEKQFCRHLILSEKGHIEWKLMY FALQKHYPAKEQYGDTLHFCRHCSILFWKDYHLALLFKDSGHPCTAADPD SCFTPVSPQHFIDLFKF
1 to 367
proprietary tag N-Terminus
Our Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.31% Glutathione, 0.79% Tris HCl
- F box only protein 25
- F box protein 25
- F box protein Fbx25
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT).
Expressed in all brain tissue observed.
Protein modification; protein ubiquitination.
Involvement in disease
Note=A chromosomal aberration involving FBXO25 is a cause of X-linked mental retardation (XLMR). Translocation t(X;8)(p11.22;p23.3) with SHROOM4.
Contains 1 F-box domain.
The F-box is necessary for the interaction with SKP1.
Nucleus. In the nucleus, associates with a subnuclear dot-like structure. Colocalized with SKP1.
Information by UniProt
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"