Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceMQVTVQSSPN FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA PEPR

Specifications

Our Abpromise guarantee covers the use of ab50128 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Functional Studies

  • Endotoxin level< 0.100 Eu/µg
  • Purity> 95 % SDS-PAGE.
    Greater than 95% by SDS-PAGE.
  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.164% Sodium phosphate, 0.44% Sodium chloride

  • ReconstitutionCentrifuge the vial prior to opening. Reconstitute in 10 mM Tris pH 8.0 to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4oC for 1 week or -20oC for future use. Repeated freeze thaw cycles will result in some loss of activity.

General Info

  • Alternative names
    • AIGF
    • Androgen induced growth factor
    • Androgen-induced growth factor
    • FGF 8
    • FGF-8
    • FGF8
    • FGF8_HUMAN
    • Fibroblast growth factor 8
    • Fibroblast growth factor 8 (androgen induced)
    • Fibroblast growth factor 8 precursor
    • HBGF 8
    • HBGF-8
    • HBGF8
    • Heparin-binding growth factor 8
    • HH6
    • KAL6
    see all
  • FunctionStimulates growth of the cells in an autocrine manner. Mediates hormonal action on the growth of cancer cells.
  • Involvement in diseaseDefects in FGF8 are the cause of Kallmann syndrome type 6 (KAL6) [MIM:612702]. Kallmann syndrome is a disorder that associates hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous.
    Defects in FGF8 are a cause of idiopathic hypogonadotropic hypogonadism (IHH) [MIM:146110]. IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function.
  • Sequence similaritiesBelongs to the heparin-binding growth factors family.
  • Developmental stageIn adults expression is restricted to the gonads.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Recombinant Human FGF8 protein (ab50128)

ab50128 has not yet been referenced specifically in any publications.

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