Recombinant Human FGFBP1 protein (ab160743)

Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MKICSLTLLSFLLLAAQVLLVEGKKKVKNGLHSKVVSEQKDTLGNTQIKQ KSRPGNKGKFVTKDQANCRWAATEQEEGISLKVECTQLDHEFSCVFAGNP TSCLKLKDERVYWKQVARNLRSQKDICRYSKTAVKTRVCRKDFPESSLKL VSSTLFGNTKPRKEKTEMSPREHIKGKETTPSSLAVTQTMATKAPECVED PDMANQRKTALEFCGETWSSLCTFFLSIVQDTSC
    • Amino acids
      1 to 234
    • Tags
      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab160743 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • 17 kDa HBGF-binding protein
    • 17 kDa heparin binding growth factor binding protein
    • 17 kDa heparin-binding growth factor-binding protein
    • FGF binding protein 1
    • FGF BP
    • FGF BP1
    • FGF-binding protein 1
    • FGF-BP
    • FGF-BP1
    • FGFBP
    • FGFBP-1
    • Fgfbp1
    • FGFP1_HUMAN
    • Fibroblast growth factor binding protein 1 precursor
    • Fibroblast growth factor-binding protein 1
    • HBp17
    see all
  • Function
    Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.
  • Tissue specificity
    Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various squamous cell carcinomas.
  • Sequence similarities
    Belongs to the fibroblast growth factor-binding protein family.
  • Cellular localization
    Secreted, extracellular space. Cell membrane. Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas.
  • Information by UniProt

Images

  • ab160743 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab160743 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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