Recombinant human FGFR1 alpha protein (Fc Chimera) (ab55758)

Overview

Description

  • NatureRecombinant
  • SourceBaculovirus
  • Amino Acid Sequence
    • AccessionP11362
    • SpeciesHuman
    • SequenceRPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGV QLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDA LPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAA KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVV PSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDK EMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTS PLYLEDPRRASIEGRGDPEEPKSCDKTHTCPPCPAPELLGGPSVFLFPPK PKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQY NSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREP QVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPP VLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG K
    • Amino acids22 to 376
    • Additional sequence informationFused with the Fc region of Human IgG1 at the C-terminus via a Xa cleavage site.

Specifications

Our Abpromise guarantee covers the use of ab55758 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity

    Determined by its ability to inhibit human FGF acidic dependent proliferation on R1 cells. The ED50 for this effect is typically at 15.0-30.0 ng/ml.

  • Applications

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.
    Purity: > 90%, by SDS-PAGE and visualised by silver stain.
  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • ReconstitutionReconstitute in PBS or medium to a concentration not lower than 50µg/ml. Soluble in water and most aqueous buffers.

General Info

  • Alternative names
    • BFGFR
    • CD331
    • CEK
    • FGFBR
    • FGFR1
    • FLG
    • FLT2
    • FMS like tyrosine kinase 2
    • HBGFR
    • KAL2
    • N SAM
    • OGD
    see all
  • RelevanceFGFR1 (fibroblast growth factor receptor 1) is a member of the fibroblast growth factor receptor family and contains an Ig-like domain and a tyrosine kinase domain. This receptor has multiple isoforms and is a Type I membrane protein. FGFR1 is widely expressed, with distinct isoforms expressed in specific tissues. FGFR1 binds fibroblast growth factor and induces mitogenesis and cellular differentiation. Defects in FGFR1 result in Pfeiffer syndrome associated with craniosynostosis. FGFR1 can be modified by phosphorylation and can bind basic/acidic fibroblast factor depending on the receptor isoform. FGFR1 has been shown to interact with N-cadherin and NCAM.
  • Cellular localizationCell Membrane

References for Recombinant human FGFR1 alpha protein (Fc Chimera) (ab55758)

ab55758 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us.

The protein is a dimer and has a MW of approximately 170 kD.

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

Use our pro...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"